一名乙型血友病伴抑制性抗体且并发类过敏反应患者实现免疫耐受。
Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction.
作者信息
Curry N S, Misbah S A, Giangrande P L F, Keeling D M
机构信息
Oxford Haemophilia Centre and Thrombosis Unit, Oxford Radcliffe Hospitals, Oxford, UK.
出版信息
Haemophilia. 2007 May;13(3):328-30. doi: 10.1111/j.1365-2516.2007.01463.x.
Abstract
We describe a young boy with severe haemophilia B who developed inhibitory antibodies and an anaphylactoid reaction to factor IX. Immune tolerance was achieved by desensitisation with escalating doses of factor IX followed by the Malmö regimen.
摘要
我们描述了一名患有严重乙型血友病的小男孩，他产生了抑制性抗体，并对凝血因子IX发生类过敏反应。通过递增剂量的凝血因子IX脱敏，随后采用马尔默方案，实现了免疫耐受。
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