Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
作者信息
Noguchi-Yachide Tomomi, Aoyama Atsushi, Makishima Makoto, Miyachi Hiroyuki, Hashimoto Yuichi
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan.
出版信息
Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. doi: 10.1016/j.bmcl.2007.04.090. Epub 2007 Apr 30.
PMID:17498949
Abstract
Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2'-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
摘要
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