Mayford Mark
Department of Cell Biology, and Institute for Childhood and Neglected Disease, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Opin Neurobiol. 2007 Jun;17(3):313-7. doi: 10.1016/j.conb.2007.05.001. Epub 2007 May 17.
The relay of extracellular signals into changes in cellular physiology involves a Byzantine array of intracellular signaling pathways, of which cytoplasmic protein kinases are a crucial component. In the nervous system, a great deal of effort has focused on understanding the conversion of patterns of synaptic activity into long-lasting changes in synaptic efficacy that are thought to underlie memory. The goal is both to understand synaptic plasticity mechanisms, such as long-term potentiation, at a molecular level and to understand the relationship of these synaptic mechanisms to behavioral memory. Although both involve the activation of multiple signaling pathways, recent studies are beginning to define discrete roles and mechanisms for individual kinases in the different temporal phases of both synaptic and behavioral plasticity.
细胞外信号转导为细胞生理变化涉及一系列错综复杂的细胞内信号通路，其中细胞质蛋白激酶是关键组成部分。在神经系统中，大量研究致力于理解突触活动模式如何转化为突触效能的持久变化，而这种变化被认为是记忆的基础。目标是在分子水平上理解诸如长时程增强等突触可塑性机制，以及理解这些突触机制与行为记忆之间的关系。尽管两者都涉及多条信号通路的激活，但最近的研究开始明确个别激酶在突触和行为可塑性不同时间阶段的离散作用和机制。
