血清tau蛋白在轻度头部外伤颅内损伤诊断中的价值。
The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma.
作者信息
Kavalci Cemil, Pekdemir Murat, Durukan Polat, Ilhan Necip, Yildiz Mustafa, Serhatlioglu Selami, Seckin Dilara
机构信息
Department of Emergency Medicine, Firat University Faculty of Medicine, Elaziğ, Turkey.
出版信息
Am J Emerg Med. 2007 May;25(4):391-5. doi: 10.1016/j.ajem.2006.10.008.
OBJECTIVE
Tau protein localizes in the axons of neuron cells, and it is released secondarily from the central nervous system because of hypoxia and trauma. In the present study, it was aimed to investigate the value of serum tau protein levels in diagnosing intracranial pathologies in minor head trauma.
METHODS
Patients were categorized into 2 groups: those without intracranial lesions in head CTs (group 1) and those with lesions in head CTs (group 2). Serum tau protein levels were determined.
RESULTS
Group 1 (n = 55) median serum tau protein level was 16.29 pg/mL (2.12-215.97 pg/mL) and group 2 (n = 33) median serum tau protein level was 18.39 pg/mL (2.19-714.47 pg/mL). Statistical analysis revealed no significant difference between the 2 groups for tau protein values, sex, age, mechanism of trauma, and Glasgow Coma Scale score.
CONCLUSION
It is suggested that serum tau protein has limited value in minor head trauma.
目的
Tau蛋白定位于神经元细胞的轴突中，因缺氧和创伤而继发于中枢神经系统释放。在本研究中，旨在探讨血清Tau蛋白水平在诊断轻度头部创伤颅内病变中的价值。
方法
将患者分为2组：头部CT无颅内病变者（第1组）和头部CT有病变者（第2组）。测定血清Tau蛋白水平。
结果
第1组（n = 55）血清Tau蛋白水平中位数为16.29 pg/mL（2.12 - 215.97 pg/mL），第2组（n = 33）血清Tau蛋白水平中位数为18.39 pg/mL（2.19 - 714.47 pg/mL）。统计学分析显示，两组在Tau蛋白值、性别、年龄、创伤机制和格拉斯哥昏迷量表评分方面无显著差异。
结论
提示血清Tau蛋白在轻度头部创伤中的价值有限。
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