Gavioli Elaine C, Rizzi Anna, Marzola Giuliano, Zucchini Silvia, Regoli Domenico, Calo' Girolamo
Department of Experimental and Clinical Medicine, Section of Pharmacology and Neuroscience Center, University of Ferrara, via Fossato di Mortara 19, 44100 Ferrara, Italy.
Peptides. 2007 Jun;28(6):1229-39. doi: 10.1016/j.peptides.2007.04.012. Epub 2007 Apr 27.
Studies showed that nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) agonists produce anxiolytic-like actions, while little is known about the effects of blockade of NOP receptor signaling in anxiety. To this aim, we investigated the behavioral phenotype of NOP receptor gene knockout mice (NOP(-/-)) in different assays. In the elevated plus-maze and light-dark box, NOP(-/-) mice displayed increased anxiety-related behavior. In the novelty-suppressed feeding behavior and elevated T-maze, NOP(-/-) mice showed anxiolytic-like phenotype, while no differences were found in the open-field, hole-board, marble-burying, and stress-induced hyperthermia. Altogether, these findings suggest that the N/OFQ-NOP receptor system modulates anxiety-related behavior in a complex manner.
研究表明，孤啡肽/痛敏肽（N/OFQ）肽受体（NOP）激动剂具有抗焦虑样作用，而关于阻断NOP受体信号传导在焦虑方面的影响却知之甚少。为此，我们在不同的实验中研究了NOP受体基因敲除小鼠（NOP(-/-)）的行为表型。在高架十字迷宫和明暗箱实验中，NOP(-/-)小鼠表现出与焦虑相关的行为增加。在新奇抑制摄食行为和高架T迷宫实验中，NOP(-/-)小鼠表现出抗焦虑样表型，而在旷场实验、洞板实验、埋珠实验和应激诱导体温过高实验中未发现差异。总之，这些发现表明N/OFQ-NOP受体系统以复杂的方式调节与焦虑相关的行为。
