记忆与焦虑的神经生物学：从基因到行为
Neurobiology of memory and anxiety: from genes to behavior.
作者信息
Kalueff Allan V
机构信息
Laboratory of Clinical Science, Division of Intramural Research Program, National Institute of Mental Health , Bethesda, MD 20892-1264, USA.
出版信息
Neural Plast. 2007;2007:78171. doi: 10.1155/2007/78171. Epub 2007 Jan 10.
Abstract
Interaction of anxiety and memory represents an essential feature of CNS functioning. This paper reviews experimental data coming from neurogenetics, neurochemistry, and behavioral pharmacology (as well as parallel clinical findings) reflecting different mechanisms of memory-anxiety interplay, including brain neurochemistry, circuitry, pharmacology, neuroplasticity, genes, and gene-environment interactions. It emphasizes the complexity and nonlinearity of such interplay, illustrated by a survey of anxiety and learning/memory phenotypes in various genetically modified mouse models that exhibit either synergistic or reciprocal effects of the mutation on anxiety levels and memory performance. The paper also assesses the putative role of different neurotransmitter systems and neuropeptides in the regulation of memory processes and anxiety, and discusses the role of neural plasticity in these mechanisms.
摘要
焦虑与记忆的相互作用是中枢神经系统功能的一个基本特征。本文综述了来自神经遗传学、神经化学和行为药理学的实验数据（以及相关临床研究结果），这些数据反映了记忆-焦虑相互作用的不同机制，包括脑内神经化学、神经回路、药理学、神经可塑性、基因以及基因-环境相互作用。通过对各种转基因小鼠模型中焦虑和学习/记忆表型的调查，本文强调了这种相互作用的复杂性和非线性，这些模型显示出突变对焦虑水平和记忆表现具有协同或相反的影响。本文还评估了不同神经递质系统和神经肽在记忆过程和焦虑调节中的假定作用，并讨论了神经可塑性在这些机制中的作用。
相似文献
1
Neurobiology of memory and anxiety: from genes to behavior.
Neural Plast. 2007;2007:78171. doi: 10.1155/2007/78171. Epub 2007 Jan 10.
2
Epigenetic modifications in neurons are essential for formation and storage of behavioral memory.
Neuropsychopharmacology. 2011 Jan;36(1):357-8. doi: 10.1038/npp.2010.125.
3
Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour.
Mol Cell Neurosci. 2010 Jun;44(2):109-17. doi: 10.1016/j.mcn.2010.02.006. Epub 2010 Mar 3.
4
S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence.
J Psychiatr Res. 2013 Nov;47(11):1791-9. doi: 10.1016/j.jpsychires.2013.08.001. Epub 2013 Aug 22.
5
Brain plasticity, memory and neurological disorders: an epigenetic perspective.
Neuroreport. 2010 Oct 6;21(14):909-13. doi: 10.1097/WNR.0b013e32833e9288.
6
Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory.
Brain Res. 2008 Nov 19;1241:103-9. doi: 10.1016/j.brainres.2008.08.080. Epub 2008 Sep 9.
7
Impaired cognitive function and reduced anxiety-related behavior in a promyelocytic leukemia (PML) tumor suppressor protein-deficient mouse.
Genes Brain Behav. 2013 Mar;12(2):189-202. doi: 10.1111/gbb.12014. Epub 2013 Jan 18.
8
Emergent properties of neural systems: how focal molecular neurobiological alterations can affect behavior.
Dev Psychopathol. 1997 Fall;9(4):907-29. doi: 10.1017/s0954579497001491.
9
Genes and neurons: molecular insights to fear and anxiety.
Genes Brain Behav. 2006;5 Suppl 2:34-47. doi: 10.1111/j.1601-183X.2006.00229.x.
10
Epigenetics of memory and plasticity.
Prog Mol Biol Transl Sci. 2014;122:305-40. doi: 10.1016/B978-0-12-420170-5.00011-8.
引用本文的文献
1
The clinical implication of β-arrestins-mediated signaling in memory and cognition.
Mol Cell Biochem. 2025 Jul 5. doi: 10.1007/s11010-025-05323-x.
2
Analysis of the Gene rs6265 Polymorphism in a Group of Women with Alcohol Use Disorder, Taking into Account Personality Traits.
Int J Mol Sci. 2024 Jun 11;25(12):6448. doi: 10.3390/ijms25126448.
3
Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer's disease.
Exp Anim. 2021 Aug 6;70(3):398-405. doi: 10.1538/expanim.21-0009. Epub 2021 Apr 9.
4
Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation.
Exp Anim. 2021 Aug 6;70(3):387-397. doi: 10.1538/expanim.21-0008. Epub 2021 Apr 8.
5
Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.
Sci Rep. 2018 Jun 5;8(1):8595. doi: 10.1038/s41598-018-26814-6.
6
Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.
Hippocampus. 2018 Aug;28(8):617-630. doi: 10.1002/hipo.22965.
7
Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and Molecular Approaches.
Front Behav Neurosci. 2016 Jan 5;9:345. doi: 10.3389/fnbeh.2015.00345. eCollection 2015.
8
Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation.
Front Integr Neurosci. 2016 Jan 8;9:67. doi: 10.3389/fnint.2015.00067. eCollection 2015.
9
γ-aminobutyric acid transporter-1 is involved in anxiety-like behaviors and cognitive function in knockout mice.
Exp Ther Med. 2015 Aug;10(2):653-658. doi: 10.3892/etm.2015.2577. Epub 2015 Jun 15.
10
Adenosine A(2A) receptors in psychopharmacology: modulators of behavior, mood and cognition.
Curr Neuropharmacol. 2009 Sep;7(3):195-206. doi: 10.2174/157015909789152191.
本文引用的文献
1
BDNF in anxiety and depression.
Science. 2006 Jun 16;312(5780):1598-9; author reply 1598-9. doi: 10.1126/science.312.5780.1598.
2
Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse.
Genes Brain Behav. 2007 Feb;6(1):77-96. doi: 10.1111/j.1601-183X.2006.00235.x.
3
Specific phobia: a disorder of fear conditioning and extinction.
CNS Spectr. 2006 Apr;11(4):248-51. doi: 10.1017/s1092852900020721.
4
Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.
J Neurosci. 2006 Mar 22;26(12):3169-81. doi: 10.1523/JNEUROSCI.5120-05.2006.
5
Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls.
ILAR J. 2006;47(2):124-31. doi: 10.1093/ilar.47.2.124.
6
Vulnerability to mild predator stress in serotonin transporter knockout mice.
Behav Brain Res. 2006 Jun 3;170(1):126-40. doi: 10.1016/j.bbr.2006.02.012. Epub 2006 Mar 20.
7
Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.
Neuroscience. 2006 Jun 19;140(1):321-34. doi: 10.1016/j.neuroscience.2006.01.049. Epub 2006 Mar 20.
8
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats.
J Neurochem. 2006 Jun;97(5):1279-87. doi: 10.1111/j.1471-4159.2006.03787.x. Epub 2006 Mar 15.
9
Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: relation to anxiolytic-like phenotype.
Behav Brain Res. 2006 May 15;169(2):325-34. doi: 10.1016/j.bbr.2006.02.002. Epub 2006 Mar 10.
10
Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress.
Pharmacol Biochem Behav. 2006 Feb;83(2):186-93. doi: 10.1016/j.pbb.2006.01.004. Epub 2006 Mar 6.
Zotero 插件