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原发性皮肤间变性CD30+大细胞淋巴瘤

[Primary cutaneous anaplastic CD30+ large cell lymphoma].

作者信息

Marrero-Calvo M D, Rodríguez-Serna M, Castejón-Calvete P, Peláez-Malagón S

机构信息

Servicio de Dermatología, Hospital San Francisco de Borja, Gandía, Valencia, España.

出版信息

Actas Dermosifiliogr. 2007 Apr;98(3):194-7.

Abstract

Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75 % of neoplastic cells. Currently it is considered a low grade lymphoma with favourable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up.

摘要

原发性皮肤间变性CD30+大细胞淋巴瘤(PCALCL)是原发性皮肤CD30+淋巴增殖性疾病谱的一部分,与淋巴瘤样丘疹病一起。它主要影响老年患者,表现为易于溃疡的皮肤结节。组织学和免疫组织化学研究显示,超过75%的肿瘤细胞表达CD30抗原。目前它被认为是一种低级别淋巴瘤,预后良好,对局部放疗、甲氨蝶呤或手术等治疗反应良好。我们报告一例93岁女性患者,其右腿出现溃疡性结节。组织学和免疫组织化学研究证实诊断为非B、非T起源的PCALCL。该患者接受了局部放疗,皮肤结节逐渐消退,随访6个月无复发。

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