前列腺癌的分级迁移：一项使用监测、流行病学和最终结果登记处数据的分析
Grade migration in prostate cancer: an analysis using the Surveillance, Epidemiology, and End Results registry.
作者信息
Jani A B, Master V A, Rossi P J, Liauw S L, Johnstone P A S
机构信息
Department of Radiation Oncology and Urology, Emory University, Atlanta, GA, USA.
出版信息
Prostate Cancer Prostatic Dis. 2007;10(4):347-51. doi: 10.1038/sj.pcan.4500977. Epub 2007 May 15.
To utilize the Surveillance, Epidemiology, and End Results (SEER) registry to examine trends in grade assignment. Data from 411 325 patients from 1984 to 2003 were analyzed for grade migration and for cause-specific survival (CSS) as a function of grade. There has been a significant grade migration during the study period (P<0.001), principally from well-differentiated (WD) to moderately differentiated (MD) disease. Five-year CSS of MD and WD patients have converged, suggesting a decreasing role of grade as a prognostic factor. A grade migration from WD to MD assignment has occurred, suggesting that prognostic categorizations based on grade across eras may be difficult to interpret.
利用监测、流行病学和最终结果（SEER）登记处的数据来研究分级分配的趋势。对1984年至2003年期间411325例患者的数据进行分析，以研究分级迁移情况以及特定病因生存率（CSS）与分级的关系。在研究期间出现了显著的分级迁移（P<0.001），主要是从高分化（WD）疾病向中分化（MD）疾病迁移。MD和WD患者的5年CSS已趋同，这表明分级作为预后因素的作用在减弱。已发生从WD到MD分级的迁移，这表明跨时代基于分级的预后分类可能难以解释。
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