Rodgers Christopher, van Zanten Sander Veldhuyzen
Division of Gastroenterology, University of Alberta, Edmonton, Canada.
Can J Gastroenterol. 2007 May;21(5):295-300. doi: 10.1155/2007/419784.
Helicobacter pylori treatment success rates have varied. A systematic review of the success rate of anti- H pylori therapy in Canada was performed.
All clinical trials containing Canadian data on the success rate of H pylori treatment were identified using MEDLINE searches, through review of references of retrieved studies and by contacting key investigators. Both randomized and open-label trials were included. Treatment effect size was calculated using a variation of Cochran's Q method.
Seventeen papers met the inclusion criteria. Both triple therapies consisting of a proton pump inhibitor (PPI), clarithromycin and either amoxicillin or metronidazole performed well, achieving a success rate of 84% and 82%, respectively. The cure rate of PPI-amoxicillin + metronidazole was 76%. Quadruple therapy consisting of a PPI, bismuth, metronidazole and tetracycline, given for seven to 10 days, achieved a success rate of 87%.
Both PPI-based triple therapy and quadruple therapy perform well in Canada for the treatment of H pylori infection.
幽门螺杆菌治疗的成功率各不相同。对加拿大抗幽门螺杆菌治疗的成功率进行了系统评价。
通过医学文献数据库检索、查阅检索到的研究的参考文献以及联系主要研究者,确定了所有包含加拿大幽门螺杆菌治疗成功率数据的临床试验。纳入了随机试验和开放标签试验。使用Cochran Q方法的一种变体计算治疗效应大小。
17篇论文符合纳入标准。由质子泵抑制剂(PPI)、克拉霉素和阿莫西林或甲硝唑组成的两种三联疗法效果良好,成功率分别为84%和82%。PPI-阿莫西林+甲硝唑的治愈率为76%。由PPI、铋剂、甲硝唑和四环素组成的四联疗法,疗程为7至10天,成功率为87%。
在加拿大,基于PPI的三联疗法和四联疗法治疗幽门螺杆菌感染的效果都很好。