多发性硬化症患者颈髓的扩散张量磁共振成像
Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis.
作者信息
Ohgiya Yoshimitsu, Oka Masaki, Hiwatashi Akio, Liu Xiang, Kakimoto Naoya, Westesson Per-Lennart A, Ekholm Sven E
机构信息
Division of Diagnostic and Interventional Neuroradiology, Department of Imaging Science, University of Rochester Medical Center, Rochester, NY, USA.
出版信息
Eur Radiol. 2007 Oct;17(10):2499-504. doi: 10.1007/s00330-007-0672-4. Epub 2007 May 16.
Our purpose was to evaluate the ability of diffusion tensor imaging (DTI) to characterize cervical spinal cord white matter (WM) in patients with multiple sclerosis (MS). DTI were obtained in 21 MS patients and 21 control subjects (CS). Regions of interest (ROIs) were placed at C2/3, C3/4, and C4/5 within the right, left, and dorsal (WM) to calculate fractional anisotropy (FA) and the apparent diffusion coefficient (ADC). Measurements in plaques and normal-appearing white matter (NAWM) of MS patients were compared with mean FA and ADC of WM in CS. FA was significantly lower in all regions in MS patients than in CS. ADC was significantly higher in all regions in MS patients than in CS except for in the dorsal WM at C2/3 and the bilateral WM at C4/5. The mean FA was 0.441 for plaques and 0.542 for NAWM, as compared with 0.739 in CS. The mean ADC was 0.810 x 10(-3) mm(2)/s for plaques and 0.722 x 10(-3) mm(2)/s for NAWM, as compared with 0.640 x 10(-3) mm(2)/s for CS. FA and ADC showed significant differences between plaques, NAWM and control WM(P < 0.01).
我们的目的是评估弥散张量成像（DTI）对多发性硬化症（MS）患者颈脊髓白质（WM）进行特征描述的能力。对21例MS患者和21例对照者（CS）进行了DTI检查。在右侧、左侧和背侧（WM）的C2/3、C3/4和C4/5水平放置感兴趣区（ROI），以计算分数各向异性（FA）和表观扩散系数（ADC）。将MS患者斑块和正常外观白质（NAWM）的测量结果与CS中WM的平均FA和ADC进行比较。MS患者所有区域的FA均显著低于CS。除C2/3背侧WM和C4/5双侧WM外，MS患者所有区域的ADC均显著高于CS。斑块的平均FA为0.441，NAWM的平均FA为0.542，而CS为0.739。斑块的平均ADC为0.810×10⁻³mm²/s，NAWM的平均ADC为0.722×10⁻³mm²/s，而CS为0.640×10⁻³mm²/s。FA和ADC在斑块、NAWM和对照WM之间存在显著差异（P<0.01）。
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