Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
Jpn J Radiol. 2013 Jan;31(1):50-5. doi: 10.1007/s11604-012-0147-7. Epub 2012 Oct 23.
We evaluated diffusional changes in normal-appearing white matter (NAWM) regions remote from multiple sclerosis (MS) plaques by using diffusional kurtosis imaging (DKI) to investigate the non-Gaussian behavior of water diffusion.
Participants were 11 MS patients and 6 age-matched healthy volunteers. DKI was performed on a 3-T MR imager. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and diffusional kurtosis (DK) maps were computed. Regions of interest (ROIs) were compared in 24 cerebral regions, including the frontal, parietal, and temporal lobe white matter (WM) in controls and NAWM in MS patients.
The mean FA of all ROIs was 0.468 ± 0.014 (SD) (controls) or 0.431 ± 0.029 (MS group) (P = 0.016). Mean ADC was 0.785 ± 0.034 × 10(-3) mm(2)/s (controls) or 0.805 ± 0.041 × 10(-3) mm(2)/s (MS group). The mean DK of all ROIs was 0.878 ± 0.020 (controls) or 0.823 ± 0.032 (MS group) (P = 0.002). Analysis of individual ROIs revealed significant differences in DK in 3 ROIs between normal WM and NAWM, but significant differences in ADC and FA in only one ROI each.
DKI may be a new sensitive indicator for detecting tissue damage in MS patients in addition to conventional diffusional evaluations, for example diffusion tensor imaging.
我们通过弥散峰度成像（DKI）评估远离多发性硬化（MS）斑块的正常表现白质（NAWM）区域的弥散变化，以研究水弥散的非高斯行为。
参与者为 11 例 MS 患者和 6 名年龄匹配的健康志愿者。在 3.0T MR 成像仪上进行 DKI。计算各向异性分数（FA）、表观扩散系数（ADC）和弥散峰度（DK）图。在包括对照组额叶、顶叶和颞叶白质（WM）以及 MS 患者 NAWM 的 24 个脑区进行了感兴趣区（ROI）比较。
所有 ROI 的平均 FA 分别为 0.468 ± 0.014（SD）（对照组）或 0.431 ± 0.029（MS 组）（P = 0.016）。平均 ADC 分别为 0.785 ± 0.034×10(-3)mm(2)/s（对照组）或 0.805 ± 0.041×10(-3)mm(2)/s（MS 组）。所有 ROI 的平均 DK 分别为 0.878 ± 0.020（对照组）或 0.823 ± 0.032（MS 组）（P = 0.002）。对单个 ROI 的分析显示，在 3 个 ROI 中，正常 WM 和 NAWM 之间的 DK 存在显著差异，但在每个 ROI 中仅存在 ADC 和 FA 的显著差异。
除了传统的弥散评估（如扩散张量成像）外，DKI 可能是一种新的敏感指标，用于检测 MS 患者的组织损伤。
