[唾液腺肿瘤中的DNA倍体与增殖活性]

[DNA ploidy and proliferative activity in salivary gland tumours].

作者信息

Driemel Oliver, Kraft Klaus, Hemmer Jörg

机构信息

Universität Regensburg, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

出版信息

Mund Kiefer Gesichtschir. 2007 Aug;11(3):139-44. doi: 10.1007/s10006-007-0060-x.

DOI:10.1007/s10006-007-0060-x

PMID:17505845

Abstract

DNA ploidy and S-Phase fraction (SPF) of 279 salivary gland tumours were analysed using high-resolution DNA flow cytometry. All 229 benign neoplasms were diploid while 12 of 50 malignant tumours showed cell populations with aneuploid DNA content. The SPF values of diploid malignancies were significantly higher if compared with pleomorphic adenomas but did not differ from that of the zystadenolymphoma (Warthin tumour) group. While aneuploidy represents a distinct indicator of malignancy SPF values are of minor relevance for dignity assessment in salivary gland tumours.

摘要

采用高分辨率DNA流式细胞术分析了279例涎腺肿瘤的DNA倍体和S期细胞分数（SPF）。所有229例良性肿瘤均为二倍体，而50例恶性肿瘤中有12例显示细胞群体具有非整倍体DNA含量。与多形性腺瘤相比，二倍体恶性肿瘤的SPF值显著更高，但与囊性腺淋巴瘤（沃辛瘤）组无差异。虽然非整倍体是恶性肿瘤的一个明显指标，但SPF值在涎腺肿瘤的良恶性评估中相关性较小。