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从注意力缺陷多动障碍到使用医学兴奋剂,再到将处方兴奋剂转用于非医学用途的兴奋剂使用:梳理其中的关联。

From attention-deficit/hyperactivity disorder to medical stimulant use to the diversion of prescribed stimulants to non-medical stimulant use: connecting the dots.

作者信息

Poulin Christiane

机构信息

Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Addiction. 2007 May;102(5):740-51. doi: 10.1111/j.1360-0443.2007.01758.x.

DOI:10.1111/j.1360-0443.2007.01758.x
PMID:17506151
Abstract

AIMS

To describe the connections among the likelihood of attention deficit/hyperactivity disorder (ADHD), medical and non-medical methylphenidate and amphetamine use and the diversion of prescribed methylphenidate in the general adolescent population.

DESIGN

Cross-sectional self-reported anonymous data from the 2002 Student Drug Use Survey in the Atlantic Provinces.

SETTING

The Atlantic provinces of Canada.

PARTICIPANTS

A total of 12,990 students participated.

MEASUREMENTS

The outcomes were a positive ADHD screening test, medical and non-medical use of methylphenidate, medical and non-medical use of amphetamine and the giving and selling of methylphenidate medication by students with a prescription. The Ontario Child Health Study Hyperactivity Scale was used to screen for ADHD.

FINDINGS

The prevalence of a positive ADHD screening test was 6% with no significant gender difference. The prevalence of medical and non-medical methylphenidate use and medical and non-medical amphetamine use was 2.0%, 6.6%, 1.2% and 8.7%, respectively. A positive ADHD screening test was independently predictive of these four patterns of use. About 26% of students with prescribed methylphenidate gave or sold some of their medication. Students in a class where at least one student had given or sold some of their prescribed pills had a 1.52-fold increased risk of non-medical methylphenidate use than their counterparts in classes where no giving or selling had taken place.

CONCLUSIONS

Connections were demonstrated at the population level between ADHD, medical methylphenidate use, the diversion of prescribed methylphenidate and the non-medical use of methylphenidate. The appropriate assessment and management of ADHD are essential to minimize both the risk of diversion and of substance use associated with unrecognized or untreated ADHD.

摘要

目的

描述注意力缺陷多动障碍(ADHD)的患病可能性、医用和非医用哌甲酯与苯丙胺的使用情况以及普通青少年人群中处方哌甲酯的转移情况之间的关联。

设计

来自2002年大西洋省份学生药物使用调查的横断面自我报告匿名数据。

地点

加拿大的大西洋省份。

参与者

共有12990名学生参与。

测量

结果包括ADHD筛查测试呈阳性、哌甲酯的医用和非医用使用、苯丙胺的医用和非医用使用以及有处方的学生给予和出售哌甲酯药物的情况。安大略儿童健康研究多动量表用于筛查ADHD。

研究结果

ADHD筛查测试呈阳性的患病率为6%,无显著性别差异。哌甲酯的医用和非医用使用率分别为2.0%和6.6%,苯丙胺的医用和非医用使用率分别为1.2%和8.7%。ADHD筛查测试呈阳性可独立预测这四种使用模式。约26%有处方哌甲酯的学生给予或出售了部分药物。在至少有一名学生给予或出售了部分处方药丸的班级中,学生非医用使用哌甲酯的风险比在未发生给予或出售情况的班级中的同龄人高1.52倍。

结论

在人群层面上,ADHD、医用哌甲酯使用、处方哌甲酯的转移以及哌甲酯的非医用使用之间存在关联。对ADHD进行适当的评估和管理对于将与未识别或未治疗的ADHD相关的转移风险和物质使用风险降至最低至关重要。

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