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对呼吸道病毒的固有免疫

Innate immunity to respiratory viruses.

作者信息

Wang Jennifer P, Kurt-Jones Evelyn A, Finberg Robert W

机构信息

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

出版信息

Cell Microbiol. 2007 Jul;9(7):1641-6. doi: 10.1111/j.1462-5822.2007.00961.x. Epub 2007 May 15.

Abstract

Pattern recognition receptors are critically involved in the development of innate and adaptive antiviral immunity. Innate immune activation by viruses may occur via cell surface, intracellular and cytosolic pattern recognition receptors. These receptors sense viral components and may activate unique downstream pathways to generate antiviral immunity. In this article, we summarize the pattern recognition receptors that recognize major human respiratory viral pathogens, including influenza virus, respiratory syncytial virus and adenovirus. We also provide an overview of the current knowledge of regulation of type I interferons and inflammatory cytokines in viral infection.

摘要

模式识别受体在先天性和适应性抗病毒免疫的发展中起着关键作用。病毒引起的先天性免疫激活可能通过细胞表面、细胞内和胞质模式识别受体发生。这些受体感知病毒成分,并可能激活独特的下游途径以产生抗病毒免疫力。在本文中,我们总结了识别主要人类呼吸道病毒病原体(包括流感病毒、呼吸道合胞病毒和腺病毒)的模式识别受体。我们还概述了目前关于病毒感染中I型干扰素和炎性细胞因子调节的知识。

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