转化生长因子β受体1*6A是家族性非综合征性结直肠肿瘤的易感等位基因吗？
Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?
作者信息
Daley Denise, Morgan Wendi, Lewis Susan, Willis Joseph, Elston Robert C, Markowitz Sanford D, Wiesner Georgia L
机构信息
Department of Epidemiology, University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):892-4. doi: 10.1158/1055-9965.EPI-06-0965.
Our analysis definitely excludes the possibility of the TGFBR16A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR16A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.
我们的分析明确排除了在我们的样本群体中，TGFBR16A等位基因增加结直肠肿瘤发生风险的可能性。最近一项验证结直肠癌与9号染色体q臂连锁关系的研究，也排除了TGFBR16A等位基因是该样本中致病变异的可能性。我们得出结论，在9q22.2 - 31.2区域仍存在一个未确定的易感基因座。
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