眼部药物递送：分子、细胞与基因

Ocular drug delivery: molecules, cells, and genes.

作者信息

Liu Xuyang, Brandt Curtis R, Rasmussen Carol A, Kaufman Paul L

机构信息

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705-3611, USA.

出版信息

Can J Ophthalmol. 2007 Jun;42(3):447-54.

PMID:17508043

Abstract

Recent advances in molecular cell biology have led to the exploration of new therapies based on molecules, cells, and genes to treat a variety of ocular disorders. In this review, we present the current state of knowledge pertaining to the development of different delivery systems to mediate safe and long-lived therapies, with an emphasis on gene therapy. The advantages and limitations of these delivery and therapeutic methods are also discussed.

摘要

分子细胞生物学的最新进展促使人们探索基于分子、细胞和基因的新疗法，以治疗各种眼部疾病。在这篇综述中，我们介绍了有关不同递送系统发展的当前知识状态，这些系统旨在介导安全且持久的治疗，重点是基因治疗。我们还讨论了这些递送和治疗方法的优缺点。