Montoya A, Pelletier M, Achim A M, Lal S, Lepage M
Grupo de Imagen Cerebral, Departamento de Psiquiatría, Neurología y Neurocirugía, Universidad de McGill, Montreal (Canadá).
Actas Esp Psiquiatr. 2007 May-Jun;35(3):176-81.
We used an event related functional magnetic resonance imaging (fMRI) method to examine the neural basis of associative recognition memory deficit in schizophrenia.
Fifteen people with schizophrenia and 18 healthy control subjects were scanned with fMRI while performing a memory task (coding and recognition) of visual objects. During coding, the subjects studied items and pairs of items. During recovery, the subjects had to recognize items (old/new decisions) and recognize associations (intact/rearranged decisions). The study design was based on a random effect model and the fMRI analysis was restricted to correct items only.
At the behavioral level, both groups performed equally well on item recognition, whereas people with schizophrenia demonstrated poorer performance on associative recognition. At the brain level, comparison between associative and item recognition tasks revealed greater left dorsolateral prefrontal and right inferior prefrontal activations in the control group relative to the schizophrenia group.
The findings of this fMRI study suggest the prefrontal cortex as the basis for the selective memory deficit for associative recognition observed in schizophrenia.
我们采用事件相关功能磁共振成像（fMRI）方法来研究精神分裂症患者联想识别记忆缺陷的神经基础。
对15名精神分裂症患者和18名健康对照者进行fMRI扫描，同时让他们执行视觉物体的记忆任务（编码和识别）。在编码阶段，受试者学习物品及物品对。在恢复阶段，受试者必须识别物品（新旧判断）并识别关联（完整/重新排列判断）。研究设计基于随机效应模型，fMRI分析仅局限于正确的物品。
在行为水平上，两组在物品识别方面表现相当，但精神分裂症患者在联想识别方面表现较差。在脑水平上，联想识别任务与物品识别任务的比较显示，相对于精神分裂症组，对照组左侧背外侧前额叶和右侧前额叶下部激活更强。
这项fMRI研究结果表明前额叶皮质是精神分裂症患者中观察到的联想识别选择性记忆缺陷的基础。
