Verhave J C, Wetzels J F M, Bakker S J L, Gansevoort R T
Ned Tijdschr Geneeskd. 2007 May 5;151(18):1002-4.
A glomerular filtration rate (GFR) <60 ml/min/1.73 m2 is associated with an increased risk of cardiovascular disease and renal insufficiency. The formula of the 'Modification of diet in renal disease' (MDRD) study is derived from plasma-creatinine concentrations and estimates GFR based on age, sex and race. Many clinical laboratories have started to report estimated GFR using this formula, which may lead to earlier recognition of chronic kidney disease. Clinicians should understand for which patients the MDRD formula may be appropriate and be aware of its limitations.
肾小球滤过率（GFR）<60 ml/分钟/1.73平方米与心血管疾病和肾功能不全风险增加相关。“肾脏病饮食改良”（MDRD）研究公式源自血肌酐浓度，并根据年龄、性别和种族估算GFR。许多临床实验室已开始使用该公式报告估算的GFR，这可能会使慢性肾病得到更早的识别。临床医生应了解哪些患者适合使用MDRD公式，并知晓其局限性。
