Seo Sang Won, Hwa Lee Byung, Kim Eun-Joo, Chin Juhee, Sun Cho Yoon, Yoon Uicheul, Na Duk L
Stroke. 2007 Jun;38(6):1949-51. doi: 10.1161/STROKEAHA.106.477315. Epub 2007 May 17.
Despite many studies investigating the association between the ischemic changes and cognitive impairment in subcortical vascular dementia (SVaD), few studies correlated cognitive impairment with microbleeds (MBs) frequently seen in SVaD.
Participants consisted of 86 patients with SVaD who fulfilled the criteria proposed by Erkinjuntti et al.
MBs occurred in 73 of 86 (84.9%) patients with SVaD. MBs were most commonly distributed in the cortex, and the cortical MBs were most pronounced in the temporoparietal area. A multiple regression showed that the number of cerebral MB was an independent predictor of cognitive impairment in multiple domains and the severity of dementia even after controlling confounding factors such as age, education, ischemic severity, and number of lacunes.
These results indicate that cerebral MB is one of the important factors that cause cognitive impairments in SVaD.
尽管有许多研究探讨了皮质下血管性痴呆（SVaD）中缺血性改变与认知障碍之间的关联，但很少有研究将认知障碍与SVaD中常见的微出血（MBs）联系起来。
参与者包括86例符合Erkinjuntti等人提出标准的SVaD患者。
86例SVaD患者中有73例（84.9%）出现MBs。MBs最常见于皮质，且颞顶叶区域的皮质MBs最为明显。多元回归显示，即使在控制了年龄、教育程度、缺血严重程度和腔隙数量等混杂因素后，脑MB的数量仍是多个领域认知障碍和痴呆严重程度的独立预测因素。
这些结果表明，脑MB是导致SVaD认知障碍的重要因素之一。
