Ding Yan, Zhu Yan-Li, Zhang Mei-Feng
Nursing Department, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.
Cancer Nurs. 2007 May-Jun;30(3):243-51. doi: 10.1097/01.NCC.0000270703.57166.e2.
The purpose of this study was to describe the quality of life of patients with ovarian malignancies during chemotherapy under condition of no recurrence and to explore changes in quality of life during chemotherapy and factors associated with quality of life. It was a cohort study during treatment. Quality of life of 75 patients with ovarian malignancies at baseline, reduced to 63 and 61 patients at later points, was assessed by the Functional Assessment of Cancer Therapy-Ovarian scale in the gynecologic wards of the Obstetrics and Gynecology Hospital affiliated to Fu Dan University within 1 to 2 days after the second, fourth, and sixth cycles of chemotherapy. During chemotherapy, under condition of no recurrence, the overall quality of life was at the middle or upper level and improved significantly over time (P = .044). There were significant improvements in physical well-being and additional concerns, whereas there was significant deterioration in social well-being. Emotional and functional well-being showed a trend toward improvement (not statistically significant). The relationship with doctors showed a significant difference between the first time point and each of the other two. Economic condition and intrafamily support were key factors for predicting the quality of life of these patients in all assessments. These findings give insights into the quality of life of women with ovarian cancer during chemotherapy and imply that nurses and other medical professionals should provide continuing support to them in accordance with their needs. Furthermore, nurses should help prevent them from social isolation as a consequence of their illness and treatment and acknowledge family members as a major support resource.
本研究的目的是描述卵巢恶性肿瘤患者在化疗期间无复发情况下的生活质量，并探讨化疗期间生活质量的变化以及与生活质量相关的因素。这是一项治疗期间的队列研究。在复旦大学附属妇产科医院妇科病房，于化疗第二、四、六个周期后的1至2天内，采用癌症治疗功能评估-卵巢量表对75例卵巢恶性肿瘤患者的生活质量进行评估，基线时75例，之后分别降至63例和61例。在化疗期间，在无复发的情况下，总体生活质量处于中高水平，且随时间显著改善（P = 0.044）。身体状况和其他担忧方面有显著改善，而社会状况有显著恶化。情绪和功能状况呈改善趋势（无统计学意义）。首次评估与另外两次评估在与医生的关系方面存在显著差异。在所有评估中，经济状况和家庭内部支持是预测这些患者生活质量的关键因素。这些发现有助于深入了解卵巢癌女性化疗期间的生活质量，并意味着护士和其他医疗专业人员应根据她们的需求为其提供持续支持。此外，护士应帮助预防她们因疾病和治疗而导致的社会隔离，并认可家庭成员作为主要支持资源的作用。
