Lim Siew-Eng, Back Michael, Quek Esther, Iau Philip, Putti Thomas, Wong John E L
Department of Hematology-Oncology, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
World J Surg. 2007 Jul;31(7):1387-92. doi: 10.1007/s00268-007-9086-3. Epub 2007 May 18.
The incidence of breast cancer in Singapore, reflecting cancer trends of developed nations, is rising rapidly. It is the most common cancer in Singaporean women. Given the significant problem that breast cancer poses, this study reports the clinical-pathologic features of 1,165 women with invasive breast cancer managed at a university teaching hospital in Singapore.
All patients who were diagnosed, treated, and followed-up at this institution between 1990 and 2002 were analyzed. Data were obtained from the National University Hospital Breast Cancer Registry.
Of our patients, 82% were ethnic Chinese. The median age of presentation was 49 years, and 24.5% of our patients presented with stage I disease. In addition, 51% of premenopausal and 60% of postmenopausal patients stained positive for estrogen receptor. Mastectomy was the most common surgical therapy, and about 90% of patients received adjuvant therapy. At a median follow-up of 81 months, the median 5-year survival was as follows: stage I, 97%, stage II, 78%, stage III, 52%, and stage IV, 13%.
This study supports what has been observed among breast cancer patients in this region and reflects a profile of breast cancer that differs from that seen in the West: patients present at a younger age, with more advanced stage and fewer estrogen-positive tumors. Most women in our series received systemic adjuvant therapy, and the 5-year overall survival rates are equivalent to published results from the West. The unique features of the disease in women in Singapore are important to recognize, as they may influence future prevention and management strategies for Asian women with breast cancer.
新加坡乳腺癌的发病率正迅速上升，反映出发达国家的癌症趋势。它是新加坡女性中最常见的癌症。鉴于乳腺癌所带来的重大问题，本研究报告了在新加坡一所大学教学医院接受治疗的1165例浸润性乳腺癌女性患者的临床病理特征。
分析了1990年至2002年间在该机构诊断、治疗和随访的所有患者。数据来自国立大学医院乳腺癌登记处。
我们的患者中，82%为华裔。发病的中位年龄为49岁，24.5%的患者表现为I期疾病。此外，51%的绝经前患者和60%的绝经后患者雌激素受体染色呈阳性。乳房切除术是最常见的手术治疗方式，约90%的患者接受了辅助治疗。中位随访81个月时，5年生存率中位数如下：I期为97%，II期为78%，III期为52%IV期为13%。
本研究支持了该地区乳腺癌患者中所观察到的情况，反映出与西方所见不同的乳腺癌特征：患者发病年龄较轻，分期较晚，雌激素阳性肿瘤较少。我们系列中的大多数女性接受了全身辅助治疗，5年总生存率与西方公布的结果相当。认识到新加坡女性该疾病的独特特征很重要，因为它们可能会影响亚洲乳腺癌女性未来预防和管理策略。
