Okabayashi Takehiro, Nishimori Isao, Sugimoto Takeki, Iwasaki Shinji, Akisawa Naoaki, Maeda Hiromichi, Ito Satoshi, Onishi Saburo, Ogawa Yasuhiro, Kobayashi Michiya, Hanazaki Kazuhiro
Department of Surgery, Kochi Medical School, Kohasu-Okocho, Nankoku City, Kochi, Japan.
Dig Dis Sci. 2008 Jan;53(1):204-9. doi: 10.1007/s10620-007-9844-y. Epub 2007 May 18.
The aim of this work was to study the benefit of supplementation with a branched chain amino acids enriched nutrient mixture on the physical and mental condition following hepatic surgery in patients with hepatocellular carcinoma (HCC). A total of 41 patients with HCC who underwent hepatic surgery (36 hepatic resection and five radiofrequency ablation therapy) were enrolled in this comparative study. These patients were divided into two groups: 13 patients received perioperative supplementation of a branched chain amino acids enriched nutrient mixture (AEN group) and 28 patients did not (control group). Between these two groups, laboratory data, postoperative complications and the length of hospital stay were analyzed comparatively. Restoration of peripheral lymphocyte count and serum total cholesterol level at 3 months after the operation was significantly faster in the AEN group than in the control group (P < 0.05). The length of hospitalization in the AEN group was significantly shorter than in the control group (P < 0.05). This preliminary case control study suggested that the perioperative supplementation of a branched chain amino acids enriched nutrient mixture is of clinical benefit for nutritional support of patients surgically managed for HCC in chronic liver disease.
这项工作的目的是研究补充富含支链氨基酸的营养混合物对肝细胞癌（HCC）患者肝切除术后身心状况的益处。共有41例接受肝脏手术的HCC患者（36例行肝切除术，5例行射频消融治疗）纳入了这项对照研究。这些患者被分为两组：13例患者接受围手术期补充富含支链氨基酸的营养混合物（AEN组），28例患者未接受补充（对照组）。对这两组患者的实验室数据、术后并发症和住院时间进行了比较分析。术后3个月时，AEN组外周淋巴细胞计数和血清总胆固醇水平的恢复明显快于对照组（P<0.05）。AEN组的住院时间明显短于对照组（P<0.05）。这项初步的病例对照研究表明，围手术期补充富含支链氨基酸的营养混合物对慢性肝病中接受手术治疗的HCC患者的营养支持具有临床益处。
