Kim W G, Park K D, Mohammad S F, Kim S W
Department of Pharmaceutics/CCCD, Salt Lake City, UT 84108.
ASAIO Trans. 1991 Jul-Sep;37(3):M148-9.
The influence of an SPUU-PEO-Heparin (B-PEO-HEP) copolymer coated blood contacting surface on patency and platelet deposition in small diameter (4 mm i.d.) Biomer grafts was investigated using a canine model. Grafts were implanted in the bilateral carotid and femoral arteries. B-PEO-HEP coated grafts still showed patency after 3 days. Control Biomer grafts occluded before 24 hr. (postoperatively). SEM of the luminal surfaces of the Biomer grafts demonstrated large amounts of adherent platelets with distorted morphologies, while B-PEO-HEP grafts did not. In platelet studies, B-PEO-HEP grafts showed significantly less platelet adhesion than Biomer grafts. The improved blood compatibility of B-PEO-HEP graft co-polymer coatings attests to their usefulness for coating or casting.
使用犬类模型研究了SPUU-PEO-肝素（B-PEO-HEP）共聚物涂层的血液接触表面对小直径（内径4mm）Biomer移植物通畅性和血小板沉积的影响。移植物植入双侧颈动脉和股动脉。B-PEO-HEP涂层移植物在3天后仍保持通畅。对照Biomer移植物在术后24小时内堵塞。Biomer移植物管腔表面的扫描电镜显示有大量形态扭曲的粘附血小板，而B-PEO-HEP移植物则没有。在血小板研究中，B-PEO-HEP移植物显示出比Biomer移植物明显更少的血小板粘附。B-PEO-HEP移植物共聚物涂层改善的血液相容性证明了它们在涂层或浇铸方面的实用性。
