Han D K, Lee K B, Park K D, Kim C S, Jeong S Y, Kim Y H, Kim H M, Min B G
Polymer Chemistry Laboratory, Korea Institute of Science and Technology, Seoul.
ASAIO J. 1993 Jul-Sep;39(3):M537-41.
PU-PEO-SO3 was applied as a coating material over a newly designed Sinkhole bileaflet PU heart valve and a porous PU vascular graft. Performance and biocompatibility were evaluated using an in vivo canine shunt system between the right ventricle and pulmonary artery. The survival periods in three implantations were 14, 24, and 39 days, during which no mechanical failure occurred in any Sinkhole valve or vascular graft. Scanning electron microscopy (SEM) studies demonstrated much less platelet adhesion and thrombus formation on PU-PEO-SO3 grafts than on PU vascular grafts. Cracks in the valve leaflet were occasionally observed on PU surfaces, but not on PU-PEO-SO3. After a 39 day implantation, calcium deposition on vascular grafts was decreased as compared with valve leaflets, and calcification on PU-PEO-SO3 was much lower than on PU. These results suggest that Sinkhole valves and vascular grafts are promising, and PU-PEO-SO3 as a coating material is more blood compatible, biostable, and calcification resistant in vivo than in untreated PU.
PU-PEO-SO3被用作一种涂层材料，涂覆在新设计的陷窝双叶PU心脏瓣膜和多孔PU血管移植物上。使用右心室和肺动脉之间的体内犬类分流系统评估其性能和生物相容性。三次植入的存活期分别为14天、24天和39天，在此期间，任何陷窝瓣膜或血管移植物均未发生机械故障。扫描电子显微镜（SEM）研究表明，PU-PEO-SO3移植物上的血小板粘附和血栓形成比PU血管移植物上少得多。在PU表面偶尔观察到瓣膜小叶出现裂缝，但在PU-PEO-SO3上未观察到。植入39天后，与瓣膜小叶相比，血管移植物上的钙沉积减少，并且PU-PEO-SO3上的钙化比PU上的低得多。这些结果表明，陷窝瓣膜和血管移植物很有前景，并且PU-PEO-SO3作为一种涂层材料在体内比未处理的PU更具血液相容性、生物稳定性和抗钙化性。
