Ye Jin, Li Yuan, Liu Hui, Liu Xian, Zhang Xiaowen, Wang Zhenlin, Huang Zhaotong
Department of Otolaryngology, the Third Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Mar;21(6):254-8.
To compare improvement in quality of life after adenotonsillectomy in children with similar demographics but with either obstructive sleep apnea hypopnea syndrome (OSAHS) or with milder forms of sleep-disordered breathing (SDB). To evaluate the relationship between polysomnogram (PSG) results and disease-specific quality of life for children with obstructive sleep apnea 18 item survey (OSA-18).
Children with SDB who were suspected of having OSAHS were enrolled. All study participants underwent overnight PSG using standardized techniques. The effectiveness of adenotonsillectomy for the relief of SDB was evaluated by using the OSA-18. Follow-up was assessed at 6-9 months. Preoperative and postoperative OSA-18 scores for each group of children (OSAHS and mild SDB) were compared.
The study population included 51 children with SDB, and 28 of them met PSG criteria for OSAHS, the other 23 of them without OSAHS. The clinical data in the two groups were similar. OSA-18 scores were not significantly different between children with and without OSAHS. The total OSA-18 scores and the scores for all domains showed significant improvement after surgery for both groups of children (P<0.01). A comparison of mean difference in total and domain scores for the two groups of children was not significant (P>0.05). The domains of sleep disturbance, physical suffering and caregiver concerns showed significant association with PSG parameters (P<0.01). But no strong association was identified for OSA-18 total scores and other two domains (P>0.05).
Both groups of children showed a dramatic improvement in quality of life after adenotonsillectomy and the degree of improvement was similar. Fortunately, surgical therapy with adenotonsillectomy was associated with marked improvement in quality of life for children with either OSAHS or mild SDB. However, the association between PSG findings and OSA-18 scores was only moderate.
比较人口统计学特征相似但分别患有阻塞性睡眠呼吸暂停低通气综合征（OSAHS）或轻度睡眠呼吸障碍（SDB）的儿童在腺样体扁桃体切除术后生活质量的改善情况。评估多导睡眠图（PSG）结果与阻塞性睡眠呼吸暂停18项调查问卷（OSA - 18）所反映的疾病特异性生活质量之间的关系。
纳入疑似患有OSAHS的SDB儿童。所有研究参与者均采用标准化技术进行夜间PSG检查。使用OSA - 18评估腺样体扁桃体切除术缓解SDB的有效性。在6 - 9个月时进行随访。比较每组儿童（OSAHS组和轻度SDB组）术前和术后的OSA - 18评分。
研究人群包括51例SDB儿童，其中28例符合OSAHS的PSG标准，另外23例不符合OSAHS标准。两组的临床数据相似。有和没有OSAHS的儿童之间OSA - 18评分无显著差异。两组儿童术后的OSA - 18总分及所有领域得分均有显著改善（P<0.01）。两组儿童总分及领域得分的平均差异比较无显著意义（P>0.05）。睡眠障碍、身体不适和照料者担忧领域与PSG参数有显著相关性（P<0.01）。但OSA - 18总分及其他两个领域未发现强相关性（P>0.05）。
两组儿童在腺样体扁桃体切除术后生活质量均有显著改善，且改善程度相似。幸运的是，腺样体扁桃体切除术这一手术治疗方法使OSAHS或轻度SDB儿童的生活质量得到显著改善。然而，PSG检查结果与OSA - 18评分之间的相关性仅为中等。
