Pereira-Filho Valfrido Antonio, Chaves Marcelo Donizetti, Haddad Jorge, Gabrielli Mario Francisco Real, Gabrielli Marisa Aparecida Cabrini, Hochulli-Vieira Eduardo, Vargas Pablo Agustin
Department of Oral and Maxillofacial Surgery, Araraquara Dental School, UNESP, Sao Paulo, Brazil.
Gen Dent. 2007 May-Jun;55(3):224-7.
Adenocarcinoma of the lung that metastasizes to the mandible is very uncommon; only a few cases have been described in the English-language literature. This article presents a metastasis from adenocarcinoma of the lung affecting the mandible of a 64-year-old woman, in which the first discovered metastatic lesion was detected before the primary tumor. The immunoreactivity for human thyroid transcription factor-1 (TTF-1) in the oral lesion was essential for determining the site and type of the primary tumor, as the patient showed no clinical or radiographic evidence of a tumor in the thyroid gland. After the primary tumor in the lung was diagnosed, radiotherapy and chemotherapy were initiated; unfortunately, the patient died two months after the start of treatment. This article emphasizes the importance of a well-conducted examination for diagnosing metastatic oral lesions.
肺腺癌转移至下颌骨非常罕见；英文文献中仅描述过少数病例。本文介绍了一例64岁女性肺腺癌转移至下颌骨的病例，其中首次发现的转移病灶在原发肿瘤之前被检测到。由于患者甲状腺无临床或影像学肿瘤证据，口腔病变中人类甲状腺转录因子-1（TTF-1）的免疫反应性对于确定原发肿瘤的部位和类型至关重要。在诊断出肺部原发肿瘤后，开始了放疗和化疗；不幸的是，患者在治疗开始两个月后死亡。本文强调了进行全面检查以诊断转移性口腔病变的重要性。
