Parsons R B, Farrant J K, Price G C, Subramaniam D, Austen B M
Department of Basic Medical Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Biochem Soc Trans. 2007 Jun;35(Pt 3):577-82. doi: 10.1042/BST0350577.
Statins inhibit the dimerization of beta-secretase [BACE (beta-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal sequence for these reactions in the assembly of the BACE complex, which may provide targets for the treatment of Alzheimer's disease.
他汀类药物通过抑制β-分泌酶[β-位点淀粉样前体蛋白裂解酶（BACE）]及相关蛋白的脂化作用来抑制其二聚化。我们的研究已经证明了在BACE复合物组装过程中这些反应有明确的时间顺序，这可能为阿尔茨海默病的治疗提供靶点。
