Nakamura T, Shimizu Y, Matsui T, Okumura N, Takimoto Y
Department of Physiological Artificial Organs, Kyoto University, Japan.
ASAIO Trans. 1991 Jul-Sep;37(3):M319-21.
An attempt was made to develop a tracheal or bronchial stent for nonsurgical implantation using a bronchoscope. Titanium-nickel alloy composed of 50% by weight of each metal has unique thermal shape-memory properties, with a transition temperature of 20 degrees C. Each stent consists of one wire with a diameter of 0.9 mm. It is 30 mm long with a cross-sectional profile resembling a horseshoe. The stent is designed to sustain the airway only at the cartilage rings. Tracheal cartilages of dogs were broken to make a tracheomalasia model, and 10 stents were implanted in 10 animals. The stents were made straight by cooling in liquid nitrogen and then inserted into the region of tracheomalasia. Once in place, they were warmed and recovered their initial shape. The animals were killed between 1 week and 6 months after implantation, and then examined. Nine of the ten stents were located in the implanted area. In one dog, the stent had been displaced into the bifurcation. Microscopic observation showed that the wires were gradually covered with epithelium. At 6 months, 58% were covered with epithelium.
尝试开发一种用于通过支气管镜进行非手术植入的气管或支气管支架。由每种金属重量占比50%组成的钛镍合金具有独特的热形状记忆特性，转变温度为20摄氏度。每个支架由一根直径为0.9毫米的金属丝构成。它长30毫米，横截面轮廓类似马蹄形。该支架设计为仅在软骨环处支撑气道。将犬的气管软骨破坏以制作气管软化模型，并在10只动物体内植入10个支架。支架在液氮中冷却后变直，然后插入气管软化区域。到位后，它们受热并恢复其初始形状。在植入后1周和6个月之间处死动物，然后进行检查。十个支架中有九个位于植入区域。在一只犬中，支架移位至分叉处。显微镜观察显示金属丝逐渐被上皮覆盖。在6个月时，58%被上皮覆盖。
