Sepe-Monti M, Pantano P, Vanacore N, De Carolis A, Bianchi V, Antonini G, Guidoni S V, Giubilei F
Department of Neurological Sciences, University of Rome La Sapienza-II Faculty, Via di Grottarossa 1035, Rome 00189, Italy.
Acta Neurol Scand. 2007 Jun;115(6):419-24. doi: 10.1111/j.1600-0404.2007.00825.x.
Subjects affected by aMCI are considered at high risk for AD. Nevertheless, the role of both vascular risk factors and WMH is matter of debate.
We enrolled consecutively 21 aMCI subjects according to Petersen Criteria; the study included routine screening for dementia, neuropsychological evaluation and brain MRI. Six vascular risk factors were assessed and WMH was quantified by means of a semiautomatic lesion-detection program.
Conversion to AD, according to NINCDS-ADRDA criteria, was 47.6%. Converters tended to be more affected by the most of vascular risk factors while no difference was noted in WMH. The best predictors of conversion to AD were scores obtained at several neuropsychological examination.
Our results show that criteria for aMCI identify subjects with a high risk to develop AD. WMH doesn't seem to have a role in progression from aMCI to AD, while some vascular risk factors seem to promote it.
患有轻度认知障碍（aMCI）的受试者被认为患阿尔茨海默病（AD）的风险很高。然而，血管危险因素和脑白质病变（WMH）的作用仍存在争议。
我们根据彼得森标准连续纳入了21名aMCI受试者；该研究包括痴呆症的常规筛查、神经心理学评估和脑部磁共振成像（MRI）。评估了六种血管危险因素，并通过半自动病变检测程序对WMH进行量化。
根据美国国立神经疾病和中风研究所 - 阿尔茨海默病及相关疾病协会（NINCDS - ADRDA）标准，转化为AD的比例为47.6%。转化者往往更容易受到大多数血管危险因素的影响，而在WMH方面未发现差异。转化为AD的最佳预测指标是在多次神经心理学检查中获得的分数。
我们的结果表明，aMCI标准识别出了发展为AD风险较高的受试者。WMH似乎在从aMCI进展到AD的过程中不起作用，而一些血管危险因素似乎会促进这种进展。
