Bonomini M, Palmieri P F, Evangelista M, Manfrini V, Albertazzi A
Institute of Nephrology, University of Chieti, Italy.
ASAIO Trans. 1991 Jul-Sep;37(3):M387-9.
The authors studied the effects of 6 months of zinc therapy on cell-mediated immunity in regular dialysis therapy patients. Serum zinc was significantly enhanced (p less than 0.01) at 2 months. While cells, OKT3, and OKT4 did not show significant variation, but after 6 months of therapy a significant (p less than 0.02) decrease of OKT8 cells, with enhancement of the OKT4/OKT8 ratio, and a significant (p less than 0.01) increase in the Multitest Composite score were found. At the same time, a significant elevation (p less than 0.001) of adenosine triphosphate (ATP), and a reduction (p less than 0.01) of lymphocyte adenosine monophosphate was seen; consequently, energy charge levels increased. Zinc-induced improvement of uremic lymphocyte function is likely mediated by an increase in intracellular ATP.
作者研究了为期6个月的锌治疗对接受常规透析治疗患者细胞介导免疫的影响。2个月时血清锌显著升高（p<0.01）。虽然细胞、OKT3和OKT4未显示出显著变化，但治疗6个月后，发现OKT8细胞显著减少（p<0.02），OKT4/OKT8比值升高，且多测试综合评分显著增加（p<0.01）。同时，三磷酸腺苷（ATP）显著升高（p<0.001），淋巴细胞单磷酸腺苷减少（p<0.01）；因此，能量电荷水平增加。锌诱导的尿毒症淋巴细胞功能改善可能是由细胞内ATP增加介导的。
