Bertoli M, Luisetto G, Arcuti V, Urso M
Department of Nephrology, University Hospital, Padova, Italy.
ASAIO Trans. 1991 Jul-Sep;37(3):M397-8.
During 7 months of calcitriol treatment in eight CAPD patients, significant increases in serum creatinine and daily excretion of this substance in dialysis fluid were observed, but there was a significant decrease in creatinine in the urinary daily output. When therapy was stopped, creatinine levels fell to baseline in serum and peritoneal fluid, and urine values continued to decrease as previously observed. Dynamometric performance showed a significant increase during treatment, which remained after drug withdrawal. These findings suggest that the transient increase of serum creatinine during calcitriol treatment may be a result of an increased production and release of this metabolite from muscle.
在八名持续性非卧床腹膜透析（CAPD）患者接受骨化三醇治疗的7个月期间，观察到血清肌酐以及该物质在透析液中的每日排泄量显著增加，但尿肌酐每日排出量显著减少。当治疗停止时，血清和腹膜液中的肌酐水平降至基线，并且尿液值如先前观察到的那样继续下降。测力计测试结果显示治疗期间有显著增加，在停药后仍保持这一状态。这些发现表明，骨化三醇治疗期间血清肌酐的短暂升高可能是由于该代谢产物从肌肉中的生成和释放增加所致。
