Murakami Takenobu, Sakuma Kenji, Nomura Takashi, Nakashima Kenji
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago 683-8504, Japan.
Neurosci Lett. 2007 Jun 8;420(1):72-5. doi: 10.1016/j.neulet.2007.04.059. Epub 2007 May 1.
Cortical excitability can be modulated by manipulation of afferent input. We investigated the influence of peripheral mixed nerve stimulation on the excitability of the motor cortex. Motor evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in the right abductor pollicis brevis (APB), extensor carpi radialis (ECR) and first dorsal interosseous (FDI) muscles were evaluated using paired-pulse transcranial magnetic stimulation (TMS) before and after high-frequency peripheral mixed nerve stimulation (150 Hz, 30 min) over the right median nerve at the wrist. The MEP amplitude and SICI of the APB muscle decreased transiently 0-10 min after the intervention, whereas the ICF did not change. High-frequency peripheral mixed nerve stimulation reduced the excitability of the motor cortex. The decrement in the SICI, which reflects the function of GABA(A)ergic inhibitory interneurons, might compensate for the reduced motor cortical excitability after high-frequency peripheral mixed nerve stimulation.
皮质兴奋性可通过传入输入的调控来调节。我们研究了外周混合神经刺激对运动皮质兴奋性的影响。在腕部对右侧正中神经进行高频外周混合神经刺激（150Hz，30分钟）前后，使用配对脉冲经颅磁刺激（TMS）评估右侧拇短展肌（APB）、桡侧腕伸肌（ECR）和第一背侧骨间肌（FDI）的运动诱发电位（MEP）、短间隔皮质内抑制（SICI）和皮质内易化（ICF）。干预后0 - 10分钟，APB肌的MEP波幅和SICI短暂降低，而ICF未改变。高频外周混合神经刺激降低了运动皮质的兴奋性。反映GABA（A）能抑制性中间神经元功能的SICI的降低，可能补偿了高频外周混合神经刺激后运动皮质兴奋性的降低。
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