Langenhuijsen Johan F, van Lin Emile N J T, Kiemeney Lambertus A, van der Vight Lisette P, McColl Gill M, Visser Andries G, Witjes J Alfred
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):671-6. doi: 10.1016/j.ijrobp.2007.04.009. Epub 2007 May 23.
To report the complication rate and risk factors of transrectally implanted gold markers, used for prostate position verification and correction procedures.
In 209 consecutive men with localized prostate cancer, four gold markers (1 x 7 mm) were inserted under ultrasound guidance in an outpatient setting, and the toxicity was analyzed. All patients received a questionnaire regarding complications after marker implantation. The complications and risk factors were further evaluated by reviewing the medical charts.
Of the 209 men, 13 (6.2%) had a moderate complication, consisting of pain and fever that resolved after treatment with oral medication. In 1.9% of the men, minor voiding complaints were observed. Other minor transient complications, defined as hematuria lasting >3 days, hematospermia, and rectal bleeding, occurred in 3.8%, 18.5%, and 9.1% of the patients, respectively. These complications were seen more often in patients with advanced tumor stage, younger age, and shorter duration of hormonal therapy.
Transrectal gold marker implantation for high-precision prostate radiotherapy is a safe and well-tolerated procedure.
报告用于前列腺位置验证和校正程序的经直肠植入金标记物的并发症发生率及风险因素。
在209例连续性局限性前列腺癌男性患者中，于门诊超声引导下植入4枚金标记物（1×7毫米），并分析毒性反应。所有患者均收到一份关于标记物植入后并发症的调查问卷。通过查阅病历进一步评估并发症及风险因素。
209例男性患者中，13例（6.2%）出现中度并发症，表现为疼痛和发热，经口服药物治疗后缓解。1.9%的男性患者出现轻微排尿不适。其他轻微短暂并发症，定义为血尿持续超过3天、血精症和直肠出血，分别发生在3.8%、18.5%和9.1%的患者中。这些并发症在肿瘤分期较晚、年龄较轻和激素治疗时间较短的患者中更常见。
经直肠植入金标记物用于高精度前列腺放疗是一种安全且耐受性良好的操作。
