Suzuki Masaaki, Saigusa Hanako, Furukawa Taiji
Department of Otolaryngology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605 Tokyo, Japan.
Sleep Med. 2007 Nov;8(7-8):773-8. doi: 10.1016/j.sleep.2007.01.013. Epub 2007 May 23.
Obstructive sleep apnea-hypopnea syndrome (OSAHS) patients undergo continuous positive airway pressure (CPAP) treatment for the first time on titration night, and then the effect of overnight CPAP treatment is estimated immediately. The purpose of this study is to compare the effects of CPAP-pretreated and non-pretreated on patients with OSAHS.
Prospective randomized, controlled parallel study was performed. Seventy patients with OSAHS received autoadjusted CPAP treatment for 2 months and then received the standard manual titration (CPAP-pretreated group). The other 70 did not receive any CPAP treatment before receiving the standard manual titration (non-CPAP-pretreated group).
The CPAP-pretreated group had significantly improved sleep efficiency and arousal index in non-rapid eye movement (NREM) sleep compared with the initial CPAP group at titration, whereas there were no significant differences between the two groups in other sleep parameters. Eight patients in the non-CPAP-pretreated group discontinued CPAP treatment 9 months after the titration, whereas one patient in the CPAP-pretreated group discontinued treatment.
A preceding CPAP treatment showed minimal effects on sleep parameters on titration night and subsequent CPAP compliance rate, although it was speculated that this preceding treatment might be of benefit for better compliance in some patients.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者在滴定夜首次接受持续气道正压通气（CPAP）治疗，然后立即评估整夜CPAP治疗的效果。本研究的目的是比较CPAP预处理和未预处理对OSAHS患者的影响。
进行前瞻性随机对照平行研究。70例OSAHS患者接受自动调压CPAP治疗2个月，然后接受标准手动滴定（CPAP预处理组）。另外70例在接受标准手动滴定前未接受任何CPAP治疗（非CPAP预处理组）。
与滴定初始CPAP组相比，CPAP预处理组非快速眼动（NREM）睡眠中的睡眠效率和觉醒指数显著改善，而两组在其他睡眠参数上无显著差异。非CPAP预处理组中有8例患者在滴定9个月后停止CPAP治疗，而CPAP预处理组中有1例患者停止治疗。
先前的CPAP治疗对滴定夜的睡眠参数和随后的CPAP依从率影响最小，尽管据推测这种先前的治疗可能对某些患者更好的依从性有益。
