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手术与持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者的长期疗效及影响比较。

A comparison of the long-term outcome and effects of surgery or continuous positive airway pressure on patients with obstructive sleep apnea syndrome.

作者信息

Lin Shih-Wei, Chen Ning-Hung, Li Hsueh-Yu, Fang Tuan-Jen, Huang Chong-Chi, Tsai Yiang-Huang, Lee Cheng-Huei

机构信息

Department of Pulmonary and Critical Care Medicine, Sleep Center, Chang-Gung Memorial Hospital, Chang Gung Institute of Technology, Chang Gung University, Taipei, Taiwan.

出版信息

Laryngoscope. 2006 Jun;116(6):1012-6. doi: 10.1097/01.mlg.0000217242.16814.da.

Abstract

OBJECTIVES

To compare the long-term (3-year) outcome and effects of continuous positive airway pressure (CPAP) and extended uvulopalatoplasty (EUPF) treatment on patients with obstructive sleep apnea syndrome.

METHODS

Eighty-four patients who received CPAP titration and bought a CPAP machine to use from March 2000 to October 2001 were included as the CPAP group. Another 55 patients who underwent EUPF surgery were included as the EUPF group. Overnight polysomnography was performed 6 months and 3 years after CPAP titration or EUPF. The disease-specific questionnaire-Snore Outcome Survey (SOS), Epworth Sleepiness Scale (ESS), and the generic health questionnaire-MOSF-36 were administered at the 6-month and 3-year follow-up examinations.

RESULTS

The age, body mass index, respiratory disturbance index, and ESS before treatment were higher in the CPAP group. The snore index was higher in the surgery group. Fifty-four patients (64.3%) in CPAP group continued treatment for 6 months; the success rate for EUPF at 6 months was 82%. The polysomnographic variables improved significantly in both groups. Improvements in the SOS and ESS scores were better in surgery group than the CPAP group. The subscales of SF-36 in surgery group were more than those in CPAP group.

CONCLUSIONS

EUPF had a better effect on snoring than CPAP 6 months after treatment in patients with obstructive sleep apnea syndrome (OSAS). This effect had gradually declined at the 3-year follow-up examination. Improvement in the quality of life of OSAS patients receiving EUPF is equal to those receiving CPAP treatment.

摘要

目的

比较持续气道正压通气(CPAP)和改良悬雍垂腭咽成形术(EUPF)治疗阻塞性睡眠呼吸暂停综合征患者的长期(3年)疗效。

方法

将2000年3月至2001年10月接受CPAP滴定并购买CPAP机器使用的84例患者纳入CPAP组。另外55例行EUPF手术的患者纳入EUPF组。在CPAP滴定或EUPF术后6个月和3年进行整夜多导睡眠图检查。在6个月和3年的随访检查中,采用疾病特异性问卷-鼾声结果调查(SOS)、爱泼沃斯嗜睡量表(ESS)和通用健康问卷-MOSF-36。

结果

CPAP组治疗前的年龄、体重指数、呼吸紊乱指数和ESS较高。手术组的鼾声指数较高。CPAP组54例患者(64.3%)持续治疗6个月;EUPF在6个月时的成功率为82%。两组多导睡眠图变量均有显著改善。手术组SOS和ESS评分的改善优于CPAP组。手术组SF-36的分量表多于CPAP组。

结论

在阻塞性睡眠呼吸暂停综合征(OSAS)患者中,治疗6个月后,EUPF对打鼾的疗效优于CPAP。在3年的随访检查中,这种效果逐渐下降。接受EUPF治疗的OSAS患者的生活质量改善与接受CPAP治疗的患者相当。

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