Lindsay R M, Spanner E, Heidenheim A P, Burton H, Lindsay S, LeFebvre J M
Department of Medicine, Victoria Hospital, London, Ontario, Canada.
ASAIO Trans. 1991 Jul-Sep;37(3):M465-7.
A multicenter prospective study of short hour (SH, less than or equal to 3 hr) dialysis using a high flux membrane (AN69S) plus volumetric control (VC), versus conventional (greater than or equal to 4 hr) (CNV) cellulosic non-VC dialysis, is ongoing. The study hypothesizes that SH treatment over 1 year will provide adequate dialysis, will not increase morbidity, and may improve quality of life. To date, 112 patients have been entered, and 54 have completed 6 months, 30 by SH. There were no differences in biophysiologic parameters at 6 months. Mean hospitalization was 5.24 days per patient. The SH group had a higher (p = 0.0374) hospitalization rate because of two patients. Quality of life was similar in SH and CNV groups. The study indicates that SH dialysis is feasible, safe, and as comfortable as CNV.
一项多中心前瞻性研究正在进行，该研究对比了使用高通量膜（AN69S）加容量控制（VC）的短时间（SH，小于或等于3小时）透析与传统的（大于或等于4小时）（CNV）非容量控制的纤维素透析。该研究假设，超过1年的短时间治疗将提供充分的透析，不会增加发病率，并且可能改善生活质量。迄今为止，已有112名患者入组，54名患者已完成6个月的治疗，其中30名采用短时间透析。6个月时生物生理参数无差异。每位患者的平均住院天数为5.24天。由于两名患者，短时间透析组的住院率较高（p = 0.0374）。短时间透析组和传统透析组的生活质量相似。该研究表明，短时间透析是可行、安全的，并且与传统透析一样舒适。
