渐渐陷入沉默。（原英文表述似乎有误，推测可能是“Degraded into silence” ，按此翻译）

DegrAAAded into silence.

作者信息

Bayne Elizabeth H, White Sharon A, Allshire Robin C

机构信息

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Building, Mayfield Road, Edinburgh, EH9 3JR, UK.

出版信息

Cell. 2007 May 18;129(4):651-3. doi: 10.1016/j.cell.2007.05.004.

DOI:10.1016/j.cell.2007.05.004

PMID:17512398

Abstract

In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Bühler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

摘要

在裂殖酵母中，RNA干扰（RNAi）依赖性异染色质形成会使插入着丝粒的转基因沉默。在本期中，比勒等人（2007年）证明RNAi机制直接靶向转基因转录本。此外，他们将转基因沉默与一种类似于芽殖酵母TRAMP复合体的蛋白质复合体联系起来，该复合体通过外切体促进转录本降解。因此，不依赖RNAi的转录本降解也可能有助于异染色质基因沉默。