Layman Rachel, Olson Karin, Van Poznak Catherine
Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0848, USA.
Hematol Oncol Clin North Am. 2007 Apr;21(2):341-67. doi: 10.1016/j.hoc.2007.03.004.
Bone is an important organ that is essential to adult hematopoiesis, electrolyte balance, and locomotion. Individuals who have metastatic breast cancer involving the bone are at increased risk for skeletal complications and those who have a history of early-stage breast cancer may be at increased risk for fragility fractures. Maintaining bone integrity is critical to control the morbidity and mortality associated with fractures and other skeletal complications. The bisphosphonates have been shown to be efficacious in decreasing the risk for skeletal complications in cancer and in osteoporosis. The article reviews the use of bisphosphonates in patients who have breast cancer.
骨骼是一个重要器官，对成人造血、电解质平衡和运动至关重要。患有骨转移乳腺癌的个体发生骨骼并发症的风险增加，而有早期乳腺癌病史的个体发生脆性骨折的风险可能增加。维持骨骼完整性对于控制与骨折和其他骨骼并发症相关的发病率和死亡率至关重要。双膦酸盐已被证明可有效降低癌症和骨质疏松症患者发生骨骼并发症的风险。本文综述了双膦酸盐在乳腺癌患者中的应用。
