Abrahams Mark J
Pain Clinic, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Best Pract Res Clin Rheumatol. 2007 Apr;21(2):223-44. doi: 10.1016/j.berh.2006.12.005.
Many soft tissue complaints are associated with the development of neuropathic pain. This pain is produced by pathophysiological processes that are different to the processes involved in the generation of the inflammatory or nociceptive pain more commonly encountered in soft tissue disorders. One of the consequences of this is that neuropathic pain can often be less responsive to standard analgesic therapies. The use of alternative analgesic strategies may be necessary if we are to treat neuropathic pain successfully. This chapter aims to outline some of the clinical features associated with neuropathic pain, the aetiological factors leading to its development and the evidence base (or lack) behind current treatment strategies. It will try to provide a rational approach to the management of neuropathic pain in patients with soft tissue disorders, particularly focusing on pharmacological management. Neuropathic pain is the focus of much current research activity, particularly pharmacological research, and this chapter will attempt to identify gaps in our clinical knowledge and highlight opportunities for further research.
许多软组织疾病都与神经性疼痛的发生有关。这种疼痛是由病理生理过程产生的，这些过程与软组织疾病中更常见的炎症性或伤害感受性疼痛产生过程不同。其后果之一是，神经性疼痛通常对标准镇痛疗法的反应较差。如果我们要成功治疗神经性疼痛，可能需要使用替代镇痛策略。本章旨在概述与神经性疼痛相关的一些临床特征、导致其发生的病因因素以及当前治疗策略背后的证据基础（或缺乏证据的情况）。它将尝试为软组织疾病患者的神经性疼痛管理提供一种合理的方法，尤其侧重于药物管理。神经性疼痛是当前许多研究活动的焦点，特别是药理学研究，本章将试图找出我们临床知识中的空白，并突出进一步研究的机会。
