Chiusolo Patrizia, Reddiconto Giovanni, Farina Giuliana, Mannocci Alice, Fiorini Alessia, Palladino Mariangela, La Torre Giuseppe, Fianchi Luana, Sorà Federica, Laurenti Luca, Leone Giuseppe, Sica Simona
Hematology Department, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy.
Leuk Res. 2007 Dec;31(12):1669-74. doi: 10.1016/j.leukres.2007.03.028. Epub 2007 May 18.
Recently the influence of polymorphisms of different genes involved in metabolism of chemoterapic agents have been studied especially in childhood acute lymphoblastic leukemia (ALL). We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms on time to relapse and survival and on methotrexate (MTX) toxicity in 82 ALL adult patients. Relapse free survival and event free survival between homozygous wild-type and variant patients in both polymorphisms were not significantly different. However, we observed an association between 677TT variant and survival in a subset of ALL patients homogenously treated with MTX-based maintenance (p=0.02). In the same subgroup we confirmed the role of 677TT variant on toxicity during MTX treatment (p=0.003).
