Mangione M R, Giacomazza D, Cavallaro G, Bulone D, Martorana V, San Biagio P L
CNR, Istituto di Biofisica @ Palermo, Via Ugo La Malfa, 153 I-90146 Palermo, Italy.
Biophys Chem. 2007 Aug;129(1):18-22. doi: 10.1016/j.bpc.2007.04.013. Epub 2007 May 3.
The potential utility of kappa-carrageenan gels for preparing drug release devices is here shown. Structural properties of kappa-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by kappa-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.
本文展示了κ-卡拉胶凝胶在制备药物释放装置方面的潜在用途。通过静态光散射和流变学测量，评估了用不同盐组成制备的、含有酮洛芬钠盐作为模型药物的κ-卡拉胶凝胶的结构性质。这些性质与pH 5.5条件下的体外释放曲线相关。将凝胶基质的释放性质与两种含有相同药物的商业产品的释放性质进行了比较。结果表明：i）在该系统中，通过使用不同的阳离子浓度可以轻松控制凝胶质地；ii）κ-卡拉胶凝胶的药物释放动力学取决于基质的结构性质；iii）在经典局部应用中使用的典型间隔时间内，所有凝胶样品几乎完全释放负载的药物，这与商业产品不同。所有这些发现可为经典局部释放系统的实现提供有用的建议。
