Bourin P, Gadelorge M
Groupe d'étude des cellules souches mésenchymateuses (Gecsom), service d'ingénierie cellulaire, EFS-PM, 75 rue de Lisieux, 31300 Toulouse, France.
Transfus Clin Biol. 2007 May;14(1):120-6. doi: 10.1016/j.tracli.2007.03.012. Epub 2007 May 21.
The mesenchymal stem cells are a cell population of bone marrow, which have the capacity to differentiate towards all the cells from the locomotor apparatus. They also have immunomodulatory properties and can contribute to tissue repair, thanks to the secretion of many growth factors. Such cells are also found in the cord blood. In the same way, very close stem cells exist in great quantity in fat tissue. These cells are very good candidates in regenerative medicine. Besides, several clinical trials were carried out in order to highlight their effectiveness mainly in osseous repair and also during hematopoietic stem cells graft or cardiac repair after infarction. However, these trials will be able to develop fully only with the condition that culture techniques meeting the conditions of good manufacturing practice are set-up. This presentation gives a progress report on the whole of these subjects.
间充质干细胞是骨髓中的一群细胞，具有向运动器官的所有细胞分化的能力。它们还具有免疫调节特性，并且由于分泌多种生长因子而有助于组织修复。此类细胞也存在于脐带血中。同样，脂肪组织中大量存在非常相似的干细胞。这些细胞是再生医学中非常理想的选择。此外，已经开展了多项临床试验，主要是为了突出它们在骨修复以及造血干细胞移植或心肌梗死后心脏修复中的有效性。然而，只有建立符合良好生产规范条件的培养技术，这些试验才能充分开展。本报告给出了关于所有这些主题的进展情况。
