Sved D W, Godsey J L, Ledyard S L, Mahoney A P, Stetson P L, Ho S, Myers N R, Resnis P, Renwick A G
WIL Research Laboratories, LLC, Ashland, OH 44805, U.S.A.
Amino Acids. 2007;32(4):459-66. doi: 10.1007/s00726-007-0494-3. Epub 2007 Feb 16.
Three biodisposition studies with taurine were performed in male and female adult rats at dosages of 30 and 300 mg/kg. A single oral dose of (14)C-taurine was rapidly absorbed, distributed to tissues and excreted unchanged in urine. Elimination of radioactivity from intracellular pools was slow. Pre-treatment of animals for 14 days with unlabelled taurine did not significantly affect the fate of (14)C-taurine. At the higher dose there was more extensive excretion combined with a lower percentage of the dose in the carcass, indicating the possibility of saturation of the tubular reabsorption mechanism for taurine. Daily administration of unlabelled taurine for 14 days did not result in an increase in total taurine in the brain. The data indicate that exogenous taurine rapidly equilibrates with endogenous body pools and that any excess is rapidly eliminated by the kidneys.
在成年雄性和雌性大鼠中开展了三项牛磺酸生物处置研究，剂量分别为30毫克/千克和300毫克/千克。单次口服剂量的（14）C-牛磺酸被迅速吸收，分布到各组织，并以原形经尿液排泄。放射性从细胞内池的消除缓慢。用未标记的牛磺酸对动物进行14天预处理，对（14）C-牛磺酸的转归没有显著影响。在较高剂量下，排泄更广泛，且 carcass 中剂量的百分比更低，这表明牛磺酸肾小管重吸收机制可能存在饱和。连续14天每日给予未标记的牛磺酸并未导致脑中总牛磺酸增加。数据表明，外源性牛磺酸可迅速与内源性体内池达到平衡，任何过量的牛磺酸都会被肾脏迅速清除。
