Aguera María Luisa, Navarro María Dolores, Pérez-Calderón Rodrigo, Rodríguez-Benot Alberto, Ojeda Raquel, Valle Casimiro, Padillo Javier, Requena María José, Rodríguez Mariano, del Castillo Domingo, Aljama Pedro
Department of Nephrology, University Hospital Reina Sofia, Cordoba, Spain.
J Nephrol. 2007 Mar-Apr;20(2):173-6.
In patients with type 1 diabetes mellitus and end-stage renal disease, simultaneous pancreas-kidney transplantation is associated with increased survival when compared with solitary deceased kidney transplant or dialysis. We consider that the analysis of our long-term program (based in a single center) of simultaneous pancreas-kidney transplantation would provide valuable information for this therapeutic approach regarding patient and organ survival.
The outcome of 57 consecutive pancreas-kidney transplants patients was analyzed. The analysis included characteristics of the donor and recipient and survival rates of patients and both grafts. We also analyzed age and modality of renal replacement treatment as possible mortality risk factors.
Ten-year patient, kidney and pancreas graft survival rates were 75.8%, 57.2% and 42.7%, respectively. Censoring for patient death, the results for 10-year kidney and pancreas survival were 78.5% and 58%, respectively.
Our results add evidence to support the notion that the double and simultaneous pancreas-kidney transplantation is in fact the treatment of choice in selected patients with end-stage renal failure due to type 1 diabetes mellitus.
与单独的尸体肾移植或透析相比，1型糖尿病合并终末期肾病患者接受胰肾联合移植可提高生存率。我们认为，对我们（单一中心）的胰肾联合移植长期项目进行分析，将为这种治疗方法在患者和器官存活方面提供有价值的信息。
分析了57例连续接受胰肾移植患者的结局。分析内容包括供体和受体的特征以及患者和两个移植物的生存率。我们还分析了年龄和肾脏替代治疗方式作为可能的死亡风险因素。
10年的患者、肾脏和胰腺移植物生存率分别为75.8%、57.2%和42.7%。排除患者死亡因素后，10年的肾脏和胰腺生存率分别为78.5%和58%。
我们的结果进一步证明，胰肾联合移植实际上是1型糖尿病所致终末期肾衰竭特定患者的首选治疗方法。
