Zoppetti Giorgio, Puppini Nadia, Ospitali Francesca, Fini Adamo
IBSA, Institut Biochimique, Lugano, Switzerland.
J Pharm Sci. 2007 Jul;96(7):1729-36. doi: 10.1002/jps.20671.
Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl-beta-cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. After filtration and freeze-drying of the final solution, the final powder was examined by SEM, DSC, TGA, XRD, Raman, and FTIR spectroscopy. Experimental results confirm that an inclusion complex exists in the solid state and possible structure of the complex is briefly discussed.
孕酮以1:2的摩尔比迅速溶解在含有羟丙基-β-环糊精（HPBCD）的水溶液中，形成可溶性包合物。对最终溶液进行过滤和冷冻干燥后，通过扫描电子显微镜（SEM）、差示扫描量热法（DSC）、热重分析法（TGA）、X射线衍射法（XRD）、拉曼光谱法和傅里叶变换红外光谱法（FTIR）对最终粉末进行了检测。实验结果证实固态中存在包合物，并简要讨论了该包合物可能的结构。
