Oue Takaharu, Inoue Masami, Kubota Akio, Kuwae Yuko, Kawa Keisei
Department of Surgery, Division of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Pediatr Blood Cancer. 2008 Apr;50(4):901-2. doi: 10.1002/pbc.21265.
A 3-year-old female presented with a large tumor occupying the right thoracic space. Open biopsy revealed the pathological diagnosis of pleuropulmonary blastoma. After the first-line chemotherapy, the patient underwent surgical resection, then two courses of high-dose chemotherapy. Three years later, follicular carcinoma of the right thyroid lobe was found, so a right hemithyroidectomy was performed. Five months later, the thyroid tumor recurred. The remaining thyroid lobe was completely excised and radioiodine therapy was administered. The patient has remained tumor-free for 3 years. The etiology and treatment of the uncommon combination of pleuropulmonary blastoma and thyroid carcinoma is discussed.
一名3岁女性因右胸腔巨大肿瘤就诊。开放性活检病理诊断为胸膜肺母细胞瘤。一线化疗后，患者接受了手术切除，随后进行了两个疗程的大剂量化疗。三年后，发现右甲状腺叶滤泡癌，遂行右半甲状腺切除术。五个月后，甲状腺肿瘤复发。切除剩余甲状腺叶并给予放射性碘治疗。患者已无瘤生存3年。本文讨论了胸膜肺母细胞瘤与甲状腺癌这种罕见组合的病因及治疗。
