Nedospasov S A, Kuprash D V
Mol Biol (Mosk). 2007 Mar-Apr;41(2):355-68.
In this review we briefly discuss several central problems of modem oncoimmunology. We review the controversies surrounding the concept of immunological surveillance, as well as the problem of immunological tolerance to tumors. The discovery of tumor antigens has a great advance towards identification of possible therapeutic targets. However, antigen-specific vaccinations against cancer so far have a very limited use, mainly for prevention of virus-associated cancers, which is essentially based on anti-viral immune response. On the other hand, antibodies to cancer antigens are being widely used in cancer diagnostics, and there are remarkable examples of their therapeutic applications. The future opportunities in both theoretical and practical oncoimmunology will directly depend on further advances in basic science.
在本综述中，我们简要讨论现代肿瘤免疫学的几个核心问题。我们回顾了围绕免疫监视概念的争议，以及对肿瘤的免疫耐受问题。肿瘤抗原的发现是朝着确定可能的治疗靶点迈出的一大步。然而，迄今为止，针对癌症的抗原特异性疫苗接种的应用非常有限，主要用于预防与病毒相关的癌症，这基本上基于抗病毒免疫反应。另一方面，针对癌症抗原的抗体正广泛应用于癌症诊断，并且有其治疗应用的显著实例。肿瘤免疫学在理论和实践方面的未来机遇将直接取决于基础科学的进一步进展。
