Portmann Luc, Giusti Vittorio
Service d'endocrinologie, diabétologie et métabolisme, CHUV, 1011 Lausanne.
Rev Med Suisse. 2007 Apr 4;3(105):859-62.
While obesity has been historically considered a criteria to establish the diagnosis of hypothyroidism, the association between them is seldom encountered in patients. Nowadays the main metabolic criteria is the gain of weight in the presence of other symptoms of hypothyroidism. The large differences between the thermogenesis of hypothyroid and hyperthyroid patients underline the complex relationship of thyroid hormones and metabolic pathways. The treatment of a subclinical hypothyroidism has almost no influence on the body weight, whereas in more severe dysfunctions a weight loss is expected, usually less than 10% of body weight. Thereafter severe obesity may not be secondary to a thyroid failure.
虽然肥胖在历史上一直被视为诊断甲状腺功能减退症的一个标准，但在患者中很少遇到两者之间的关联。如今，主要的代谢标准是在存在其他甲状腺功能减退症状的情况下体重增加。甲状腺功能减退和甲状腺功能亢进患者的产热差异巨大，突显了甲状腺激素与代谢途径之间的复杂关系。亚临床甲状腺功能减退症的治疗对体重几乎没有影响，而在更严重的功能障碍中，预计体重会减轻，通常不到体重的10%。因此，严重肥胖可能并非继发于甲状腺功能衰竭。
