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[缺铁性贫血的当前治疗建议]

[Current recommendations for the treatment of iron deficiency anemia].

作者信息

Schaefer R M, Huch R, Krafft A

机构信息

Hôpital universitaire de Münster (UKM) Médecine interne D, Albert-Schweitzer-Strasse 33, D-48149 Münster.

出版信息

Rev Med Suisse. 2007 Apr 4;3(105):874-80.

Abstract

Iron deficiency is a frequent complication in chronically ill patients and in pregnant women. Iron status can now be characterised precisely and relatively easily by determining serum ferritin, transferritin saturation and if necessary hypochromic erythrocytes and the haemoglobin content of erythrocytes (CHr). Oral iron replacement is usually restricted by limited absorption and low tolerability. Intravenous iron therapy is possible in such cases and can be combined with rHuEPO (e.g. EPREX/ epoetin alfa) in severe cases. Iron saccharate (VENOFER) is commercially available in Switzerland and this permits high dose iron replacement without any danger of anaphylaxis or acute iron toxicity.

摘要

缺铁是慢性病患者和孕妇常见的并发症。现在,通过测定血清铁蛋白、转铁蛋白饱和度,必要时测定低色素红细胞和红细胞血红蛋白含量(CHr),可以精确且相对容易地确定铁状态。口服铁剂补充通常受限于吸收有限和耐受性差。在这种情况下可进行静脉铁治疗,严重时可与重组人促红细胞生成素(如EPREX/促红细胞生成素α)联合使用。蔗糖铁(VENOFER)在瑞士有商业销售,这使得高剂量铁补充成为可能,且无过敏反应或急性铁中毒的风险。

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