Fujishima Naohito, Fujishima Masumi, Inomata Mika, Yamanaka Yasuo, Saitoh Kunie, Kameoka Yoshihiro, Yoshioka Tomoko, Saitoh Hirobumi, Takahashi Naoto, Hirokawa Makoto, Sawada Ken-ichi
Division of Hematology and Oncology, Department of Medicine, Akita University School of Medicine.
Rinsho Ketsueki. 2007 Apr;48(4):326-31.
A 43-year-old female was admitted with therapy-resistant pancreatitis and an abdominal tumor around the pancreatic head. Laboratory data revealed leukocytosis with a white blood cell count of 18200/microl, 25% atypical cells and an LDH of 13410 IU/l. The bone marrow was comprised of 78.4 percent lymphoblastoid cells which were positive for CD10, CD19 and CD20, and the cytogenetic study of which demonstrated the presence of t(8;14) (q24;q32) and t(14;18) (q32;q21) in the same clone. The patient was diagnosed as having Burkitt's lymphoma (BL) with t(8;14) and t(14;18). Although CODOX-M and IVAC therapy combined with rituximab achieved complete remission, she died of rapid progressive disease during whole brain irradiation before autologous peripheral blood stem cell transplantation. Even if the intensive chemotherapy with rituximab is given adequately, durable remission may not be achieved in BL with translocation of t(8;14) and t(14;18). A more effective therapy remains to be established for the treatment of this disease.
一名43岁女性因治疗抵抗性胰腺炎及胰头周围腹部肿瘤入院。实验室检查数据显示白细胞增多，白细胞计数为18200/微升，25%为非典型细胞，乳酸脱氢酶为13410国际单位/升。骨髓中78.4%为淋巴母细胞样细胞，这些细胞CD10、CD19和CD20呈阳性，其细胞遗传学研究显示在同一克隆中存在t(8;14)(q24;q32)和t(14;18)(q32;q21)。该患者被诊断为患有伴有t(8;14)和t(14;18)的伯基特淋巴瘤（BL）。尽管采用CODOX-M和IVAC疗法联合利妥昔单抗实现了完全缓解，但她在自体外周血干细胞移植前的全脑照射期间死于疾病快速进展。即使充分给予含利妥昔单抗的强化化疗，伴有t(8;14)和t(14;18)易位的BL可能也无法实现持久缓解。仍有待确立更有效的治疗方法来治疗这种疾病。
